1723年(清雍正元年),兴发娱乐开始为清宫供御药,历经雍正、乾隆、嘉庆、道光、咸丰、同治、光绪、宣统八代皇帝,长达188年。 In 1723, the 1st Qing Yongzheng reign, Tongrentang initiated its medication supply to the Qing Imperial Palace, over the eight reigns , for 188 years.